The reversal of age was scientifically confirmed to be possible in mice in the scientific journal Cell on December 19, 2013 by Ana Gomes in the David Sinclair laboratory at Harvard Medical School. Ana used nicotinamide mononucleotide (NMN), a naturally occurring compound in cells, to reverse aging. This confirmation was of results first seen by Katheryn Ramsey and Katheryn Mills. They used nicotinamide mononucleotide (NMN) in mice in 2008 and saw age reversal effects from its use. This discovery was the culmination of research confirmed by Richard Weindruch in 1986, using calorie restriction to slow aging in mice. This was a confirmation of observations of calorie restriction elongating life by Clive Mc Cay in 1935.

Egaceutical Corporation research, starting in 2014, showed NAD+ from NMN can turn on sirtuins in humans, but sirtuins, even with available NAD+, can be turned off by cellular feedback loops. To solve this problem Egaceutical Corporation added two compounds that naturally occur in human cells to make a three-compound EGA® product. Triple-compound EGA® turns on sirtuin enzymes, starts the repair process, keeps repair on, keeps feedback loops off, and reverses aging in humans.

EGA® has been used in the first demonstrated human age reversal and a patent for it is pending.  EGA® means age reversal and is age spelled in reverse.