Best Diagnostic Tests
Inflammation markers
Interleukin-6 (IL-6)
IL-6 as a prediction for the “diseases of aging”
For mitochondrial health → Correia-Melo C 2016
For immune and auto-immune disease → Astrakhantseva IV 2004
For heart disease → Ridker P 2000
For stroke → Herder C 2011
For kidney disease → Lee B 2015
For Alzheimer’s disease → Butchart J 2015 & Holmes C 2011
For defense against bacteria → Puchta A 2016
For defense against viruses → McElroy AK 2016
For intelligence → Bettcher B 2014 (multiple) 2015
For sleep disorders → Irwin MR 2015
For physical performance → Cesari M 2004
IL-6 for longevity and all-cause mortality
Puzianowska-Kuznicka M 2016 & Arai Y 2015 & Varadhan R 2014 & Lee JK 2012 & Derhovanessian E 2010 & Bruunsgaard H 2003 & Reuben DB 2002 & Taaffe DR 2000
Also grouped with the IL-6 test in Arai Y 2015 are
Tumor necrosis factor Alpha (TNF-α)
hsCRP
CMV-IgG
Up and coming diagnostic tests for biological age that show great promise
DNA methylation (“clock”) (epigenome) → Horvath S. 2013 & Hannun G 2013
DNA methylation PhenoAge (“clock”) → Levine ME 2018
Transcriptome (“clock”) → Peters MJ 2015 & Timmons JA, specifically for human dermal fibroblasts see Fleischer JG 2018
Slow wave sleep during first non-REM → Mander BA 2017
Structural MRI of brain → Cole JH 2017
Nucleolar size → Tiku V 2016
Proteome (Circulating Protein “clock”) → Enroth S 2015
Other diagnostic tests that have shown correlation to biological age
Microbiome “clock” → Galkin F 2019
Chaparome → Labbadia J 2015
DNA breakage
NAD+ → Guarente L 2016
CD-38 → Camacho-Pereira J 2016
H2S → Perridon BW 2016
GSH/GSSG → Sies H 2015
Cysteine/Cystine → Sies H 2015
Telomere length → Blackburn E 2016
Heart rate variability → Kurita A 2013
Ability to smell → Devanand DP 2015
Ability to smell → Submant PH 2018
Impairment of meningeal lymphatic function increases with brain age → Da Mesquita S 2018
Hyper methylation of autophagy genes in macrophages → Khalil H 2016
Cell free DNA in circulating plasma mainly from apoptotic cells → Teo YV 2018
Nerve cell size for measuring intelligence → Goriounova NA 2018
Chaparome →
Tests you can do at home
Getting off the floor (touches needed) → Araujo CG 2012
Static balance (seconds on one foot) → Whitacker Wellness Institute
Skin elasticity (pull, then time to normal) → Whitacker Wellness Institute
Catching ruler (after unexpectant drop) → Whitacker Wellness Institute
Lung function (blowing out match at distance) → Whitacker Wellness Institute